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For instance, metformin, a commonly prescribed medication for type 2 diabetes, can inhibit pro-inflammatory cytokine production (including IL1 and TNF-α) and block nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling (Witham et al., 2023

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161 But of course, the degree to which acetaminophen use during circumcision is associated with autism will depend not only on the ability of acetaminophen to induce autism but also on other factors such as the relative amount of acetaminophen used following circumcision compared with other uses in the pediatric population